Heparan Sulfate Proteoglycans during Terminal Skeletal Muscle Cell Differentiation: Possible Functions and Regulation of their Expression
نویسندگان
چکیده
Heparan sulfate proteoglycans are key molecules found associated with the cell surface and extracellular matrix (ECM). These macromolecules seem to be essential to achieve terminal skeletal muscle differentiation. In this review, we present data about the types of beparan suifate proteoglycans present in skeletal muscle cells, how their expression changes during differentiation and we propose some mechanisms that might be controlling and/or affecting their expression. Finally, we discuss some possible Functions for these heparan sulfate proteoglycans during skeletal muscle differentiation.
منابع مشابه
Heparan sulfate proteoglycans are increased during skeletal muscle regeneration: requirement of syndecan-3 for successful fiber formation.
Skeletal muscle regeneration is a highly complex and regulated process that involves muscle precursor proliferation and differentiation and probably requires the participation of heparin binding growth factors such as FGFs, HGF and TGFbeta. Heparan sulfate proteoglycans, key components of cell-surfaces and ECM, modulate growth factor activities and influence cell growth and differentiation. The...
متن کاملSkeletal Muscle Satellite Cells: Identification of a Heparan Sulfate Proteoglycan
Skeletal muscle fibers are surrounded by an extracellular matrix. The extracellular matrix is composed of gly cop rote ins, collagen, and pro teogly cans. Proteoglycans have been suggested by different reports to play an important functional role in tissue differentiation. However, an understanding of how protcoglycans modulate skeletal muscle differentiation and the activation of myogenic sate...
متن کاملRepression of myogenic differentiation by aFGF, bFGF, and K-FGF is dependent on cellular heparan sulfate
We have proposed a model in which fibroblast growth factor (FGF) signalling requires the interaction of FGF with at least two FGF receptors, a heparan sulfate proteoglycan (HSPG) and a tyrosine kinase. Since FGF may be a key mediator of skeletal muscle differentiation, we examined the synthesis of glycosaminoglycans in MM14 skeletal muscle myoblasts and their participation in FGF signalling. Pr...
متن کاملRequirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation.
Basic fibroblast growth factor (bFGF) binds to heparan sulfate proteoglycans at the cell surface and to receptors with tyrosine kinase activity. Prevention of binding between cell surface heparan sulfate and bFGF (i) substantially reduces binding of fibroblast growth factor to its cell-surface receptors, (ii) blocks the ability of bFGF to support the growth of Swiss 3T3 fibroblasts, and (iii) i...
متن کاملEffects of syndecan-1 and glypican on muscle cell proliferation and differentiation: implications for possible functions during myogenesis.
The heparan sulfate proteoglycans, syndecan-1 and glypican, are low-affinity receptors for fibroblast growth factor 2 (FGF2). Because FGF2 is a potent stimulator of skeletal muscle cell proliferation and a strong inhibitor of differentiation, it is likely that changes in syndecan-1 and glypican expression will affect myogenesis as both, in part, regulate FGF-dependent signaling. In the current ...
متن کامل